I have worked with python for 5 years, and taken a vast liking and interest in professional GUI design for desktop with python, Specifically using the tkinter and pygtk libraries that are available.
I have also worked on web design using CSS, JS, HTML and php and so believe that the beauty that can be found in the power of web design should also be provided to Tkinter that looks a bit funny on its own, like something coming from 2000.
I would use XML and HTML parser libraries from python to traverse the document and retrieve various elements, and their child nodes. Those would form the basis of creating the GUI.
Gui would be developed in Tkinter but also Pygtk would be provided.
Tests would be written to ensure that it runs well.